When metabolism is less effective, the body may store unused energy as fat. In addition, poor sleep can increase the production of insulin and cortisol, which also prompt fat storage. Every individual has different varieties and amounts of bacteria in their gut. Some types can increase the amount of energy that the person harvests from food, leading to fat deposition and weight gain.
Losing even 10% of your total body weight can significantly lower your risk. What you eat and the pattern of your eating are going to determine how intermittent fasting will work for you. Practice portion control and eat till your 80% full. Feed yourself with nourishing food whenever you feel hungry, even if it requires breaking your fast.